Association between dental diseases and stroke

Haocheng Zhang; Qian Yu; Caidi Ying; Yibo Liu; Xiaoyu Wang; Yinghan Guo; Liang Xu; Yuanjian Fang; Xiaoyue Liao; Sheng Chen

Saudi Dental Journal (Nov 2024)

Association between dental diseases and stroke

Haocheng Zhang,
Qian Yu,
Caidi Ying,
Yibo Liu,
Xiaoyu Wang,
Yinghan Guo,
Liang Xu,
Yuanjian Fang,
Xiaoyue Liao,
Sheng Chen

Affiliations

Haocheng Zhang: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, China
Qian Yu: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China
Caidi Ying: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China
Yibo Liu: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China
Xiaoyu Wang: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China
Yinghan Guo: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China
Liang Xu: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, China
Yuanjian Fang: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China; Corresponding authors at: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, People's Republic of China.
Xiaoyue Liao: Department of Neurosurgery, The Second People’s Hospital of Quzhou, Zhejiang Province, China; Corresponding author.
Sheng Chen: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China; Corresponding authors at: Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, People's Republic of China.

Journal volume & issue: Vol. 36, no. 11
pp. 1389 – 1396

Abstract

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Introduction: This study aimed to analyze the existing evidence on the association between dental diseases and stroke. Various pathogenic mechanisms, including bacteraemia and systemic inflammation, were investigated to explore their impact on stroke occurrence and severity. Methods: A comprehensive literature search was conducted through the online databases PubMed, Google Scholar, Web of Science, and Scopus. The initial screening process resulted in a total of 138 articles being gathered. Upon subsequent refinement, 52 articles were discarded due to duplication or non-English language, leaving 86 articles for further assessment. Results: Oral bacteria can travel to the brain’s blood vessels and cause bacteraemia, leading to local inflammation and the release of toxins. This process can result in the blockage or rupture of blood vessels, leading to stroke. Oral infections consistently trigger immune responses and systemic inflammation, with inflammation-related proteins playing a crucial role in stroke development. Notably, periodontal treatment could reduce the risk of stroke. Conclusion: This review emphasizes the role of dental diseases in promoting stroke occurrence through various mechanisms. Dental diseases contribute to the development of stroke by facilitating bacteraemia and systemic inflammation. Furthermore, through effectively treating and preventing dental diseases, the risk of strokes can be significantly reduced.

Published in Saudi Dental Journal

ISSN: 1013-9052 (Print); 1658-3558 (Online)
Publisher: Elsevier
Country of publisher: Saudi Arabia
LCC subjects: Medicine: Dentistry
Website: https://www.journals.elsevier.com/saudi-dental-journal/

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