Green synthesis of some tetrahydroquinoline derivatives and evaluation as anticancer agents

Nuha M.M. Alanazi; Ibrahim O. Althobaiti; Yasser A. El-Ossaily; Wael A.A. Arafa; Mohamed Y. El-Sayed; Hamud A. Altaleb; Hanaa Y. Ahmed; Mahmoud S. Tolba

Arabian Journal of Chemistry (Mar 2023)

Green synthesis of some tetrahydroquinoline derivatives and evaluation as anticancer agents

Nuha M.M. Alanazi,
Ibrahim O. Althobaiti,
Yasser A. El-Ossaily,
Wael A.A. Arafa,
Mohamed Y. El-Sayed,
Hamud A. Altaleb,
Hanaa Y. Ahmed,
Mahmoud S. Tolba

Affiliations

Nuha M.M. Alanazi: Department of Chemistry, College of Science, Jouf University, Sakaka, P.O.Box 2014, Saudi Arabia; Department of Nursing, Northern College of Nursing, Arar 73311, Saudi Arabia
Ibrahim O. Althobaiti: Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
Yasser A. El-Ossaily: Department of Chemistry, College of Science, Jouf University, Sakaka, P.O.Box 2014, Saudi Arabia; Chemistry Department, Faculty of Science, Fayoum University, P.O. Box 63514, Fayoum City, Egypt; Corresponding authors at: Department of Chemistry, College of Science, Jouf University, P.O.Box 2014, Sakaka, Saudi Arabia (Y.A. El-Ossaily).
Wael A.A. Arafa: Department of Chemistry, College of Science, Jouf University, Sakaka, P.O.Box 2014, Saudi Arabia; Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia
Mohamed Y. El-Sayed: Department of Chemistry, College of Science, Jouf University, Sakaka, P.O.Box 2014, Saudi Arabia
Hamud A. Altaleb: The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo 11371, Egypt
Hanaa Y. Ahmed: Department of Chemistry, Faculty of Science, New Valley University, El-Kharja 72511, Egypt
Mahmoud S. Tolba: Chemistry Department, Faculty of Science, New Valley University, El-Kharja 72511, Egypt; Corresponding authors at: Department of Chemistry, College of Science, Jouf University, P.O.Box 2014, Sakaka, Saudi Arabia (Y.A. El-Ossaily).

Journal volume & issue: Vol. 16, no. 3
p. 104543

Abstract

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This study demonstrates the design and synthesis of heterocyclic compounds with diverse biological effects. Using an ionic liquid catalyst, a sonosynthetic approach for the assembly of bis-arylidene cycloalkanone derivatives (bis-chalcones) has been reported. Three cancer cell lines Hepatocellular carcinoma cells (HepG-2), Breast carcinoma cells (MCF-7), and Lung carcinoma cells (A-549) were utilized to investigate the antiproliferative effects of some selected samples. Many evaluated drugs exhibited good to moderate cytotoxicity against the examined cell lines. Notably, the IC50 values for the S-alkyl derivatives ranged from 2.86 to 13.14 µg/mL.

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

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