Communications Biology (Jul 2022)

Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture

  • Lukas Wettstein,
  • Philip Maximilian Knaff,
  • Christian Kersten,
  • Patrick Müller,
  • Tatjana Weil,
  • Carina Conzelmann,
  • Janis A Müller,
  • Maximilian Brückner,
  • Markus Hoffmann,
  • Stefan Pöhlmann,
  • Tanja Schirmeister,
  • Katharina Landfester,
  • Jan Münch,
  • Volker Mailänder

DOI
https://doi.org/10.1038/s42003-022-03613-4
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 12

Abstract

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This study describes the development and characterization of peptidomimetic inhibitors of TMPRSS2, which primes the Spike protein of SARS-CoV-2. The inhibitors are shown to prevent SARS-CoV-2 infection in cells as efficiently as camostat mesylate.