Atypical acute disseminated encephalomyelitis with systemic inflammation after a first dose of AztraZaneca COVID-19 vaccine. A case report

Laure Bastide; Gaetano Perrotta; Valentina Lolli; Céline Mathey; Ortensa-Irina Vierasu; Serge Goldman; Frédéric Vandergheynst

doi:10.3389/fneur.2022.995875

Frontiers in Neurology (Aug 2022)

Atypical acute disseminated encephalomyelitis with systemic inflammation after a first dose of AztraZaneca COVID-19 vaccine. A case report

Laure Bastide,
Gaetano Perrotta,
Valentina Lolli,
Céline Mathey,
Ortensa-Irina Vierasu,
Serge Goldman,
Frédéric Vandergheynst

Affiliations

Laure Bastide: Department of Neurology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
Gaetano Perrotta: Department of Neurology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
Valentina Lolli: Department of Radiology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
Céline Mathey: Department of Nuclear Medicine, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
Ortensa-Irina Vierasu: Department of Nuclear Medicine, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
Serge Goldman: Department of Nuclear Medicine, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
Frédéric Vandergheynst: Department of Internal Medicine, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium

DOI: https://doi.org/10.3389/fneur.2022.995875
Journal volume & issue: Vol. 13

Abstract

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BackgroundOnly a few cases of acute disseminated encephalomyelitis (ADEM) following coronavirus disease 19 (COVID-19) vaccination have been described since the beginning of the vaccination campaign.ResultsHere we report the first case of central nervous system (CNS) demyelination with systemic inflammatory findings on whole body 19-fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) following the ChAdOx1 nCoV-19 vaccine.ConclusionsClinicians should stay aware of potential new adverse events after immunization.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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