Asian Journal of Oncology (Jul 2019)

An Interesting Case of Lineage Switch to Histiocytic Sarcoma in a Case of Diffuse Large B Cell Lymphoma

  • Manasi C. Mundada,
  • Faiq Ahmed,
  • Sudha Murthy,
  • Krishna Mohan Mallavarapu

DOI
https://doi.org/10.1055/s-0039-3401465
Journal volume & issue
Vol. 05, no. 02
pp. 093 – 096

Abstract

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Lineage switch involves change in the phenotypic characteristics from one type to another. It is a rare phenomenon described in mature lymphoid neoplasms which transform to histiocytic/dendritic cell tumor, more commonly described in low-grade lymphoma like follicular, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), wherein the neoplasm loses the phenotypic characteristics of non-Hodgkin lymphoma and acquires the markers of histiocytic differentiation. Here, we present a case of diffuse large B cell lymphoma transforming to histiocytic sarcoma post 6 months of start of therapy. Histiocytic sarcoma being a very aggressive tumor, the patient had a very rapid deteriorating course and succumbed to disease.

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