Synthesis of Some Mannich and 2,5-Disubstituted4-Thiazolidinone Compounds Derived from 4-amino Sulphamethaoxazole

Abstract

4-Chloro acetyl amino sulphamethaoxazole (A1) was synthesized by the reaction of amino sulphamethaoxazole with chloro acetyl chloride, Then refluxed with ammonium thiocyanate to obtain thiazoldine-4-one (A 2) . (A2) was stirred with formaldehyde and various secondary amines to gain 5 novel compounds Mannich bases(A 3-7 ).and 2,5-Disubstituted thiazolidine-4-one (A 8-11) were synthesized by the reaction of substituted benzyldehyd with Compound (A2) . The structure of the synthesized compounds are confirmed by I.R, 1 H-NMR & 13 C-NMR spectra and Some chemical physical data

Keywords

• synthesis mannich bases
• disubstituted
• thiazolidinones