Nature Communications (Feb 2021)

TGFβ signalling acts as a molecular brake of myoblast fusion

  • Julie Melendez,
  • Daniel Sieiro,
  • David Salgado,
  • Valérie Morin,
  • Marie-Julie Dejardin,
  • Chan Zhou,
  • Alan C. Mullen,
  • Christophe Marcelle

DOI
https://doi.org/10.1038/s41467-020-20290-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Fusion of myoblasts is essential for muscle development and repair, but the molecular mechanism underlying this process remains unclear. Here, the authors show, using chicken embryos as a model, that TGFβ signalling inhibits fusion via a receptor complementation mechanism, and indicate the involvement of endocytic degradation of activated receptors in modulation of this process.