THE INFLUENCE OF CRYOPRESERVED PLACENTAL EXPLANTS ON OVARIES AND UTERUS RECOVERY AFTER PELVIC INFLAMMATORY DISEASE IN THE EXPERIMENT

Abstract

Pelvic inflammatory disease is the most common gynecological pathology. A number of studies have demonstrated the effectiveness of placenta derivatives for the female genital system pathology treatment. The aim of the study was to determine the effect of cryopreserved placenta explants on ovaries and uterus recovery after an infectious process. Materials and methods: Inflammation was modeled on non-linear mice by the method of puncture and ligation of the cecum, followed by antibiotic therapy. For rehabilitation, intramuscular injection of cryopreserved placenta explants of 10 mg per animal was used. The numbers of ovarian generative elements, the structure of uterus, the severity of adhesions, reproductive indices in experimental animals were studied. The results of the study and their discussion: It was found that the modeling of the infectious process leads to an increasing of adhesions formation, a decreasing of the primordial and primary follicles number, folliculogenesis suppression, a number of pregnant animals and fetuses decreasing. The placental explants application has no effect on uterine adhesions, leads to a number of all follicles increasing (except for primordial ones), number of fetuses increasing, but not the number of pregnant mice. Conclusion: The cryopreserved placental explants application after the cured infectious process does not affect adhesion formation, leads to the stimulation of folliculogenesis, uterine hypertrophy and improvement of reproductive indices due to an increasing in the number of fetuses