Pediatrics and Neonatology (Oct 2015)

Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection

  • Chao-Jen Lin,
  • Shih-Chung Wang,
  • Cheng-Lung Ku,
  • Jun-kai Kao,
  • Ming Chen,
  • Chin-San Liu

DOI
https://doi.org/10.1016/j.pedneo.2013.04.001
Journal volume & issue
Vol. 56, no. 5
pp. 346 – 350

Abstract

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A 19-month-old boy with chronic granulomatous disease (CGD) received umbilical cord blood transplantation (UCBT) from an unrelated donor after experiencing a life-threatening disseminated Bacillus Calmette–Guérin infection. After busulfan and cyclophosphamide conditioning, we performed a 5/6-matched UCBT. Engraftment and mixed chimerism was 100% in peripheral blood, and 100% of his neutrophils had normal oxidative burst activity on day 17. The patient is now 3 years old, free from infection, and growing well. To our knowledge, this is the second case of CGD treated with UCBT in Taiwan. His successful outcome illustrates that UCBT in a patient with CGD should be considered early if a human leukocyte antigen-matched donor is not available or the patient has just recovered from a severe infection.

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