Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis

Bo Ye; Dandan Fan; Weiwei Xiong; Min Li; Jian Yuan; Qi Jiang; Yuting Zhao; Jianxiang Lin; Jie Liu; Yilv Lv; Xiongjun Wang; Zhigang Li; Jianzhong Su; Yunbo Qiao

doi:10.1038/s41467-021-24813-2

Nature Communications (Jul 2021)

Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis

Bo Ye,
Dandan Fan,
Weiwei Xiong,
Min Li,
Jian Yuan,
Qi Jiang,
Yuting Zhao,
Jianxiang Lin,
Jie Liu,
Yilv Lv,
Xiongjun Wang,
Zhigang Li,
Jianzhong Su,
Yunbo Qiao

Affiliations

Bo Ye: Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University
Dandan Fan: School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University
Weiwei Xiong: Precise Genome Engineering Center, School of Life Sciences, Guangzhou University
Min Li: Precise Genome Engineering Center, School of Life Sciences, Guangzhou University
Jian Yuan: School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University
Qi Jiang: School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University
Yuting Zhao: Precise Genome Engineering Center, School of Life Sciences, Guangzhou University
Jianxiang Lin: Precise Genome Engineering Center, School of Life Sciences, Guangzhou University
Jie Liu: Precise Genome Engineering Center, School of Life Sciences, Guangzhou University
Yilv Lv: Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University
Xiongjun Wang: Precise Genome Engineering Center, School of Life Sciences, Guangzhou University
Zhigang Li: Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University
Jianzhong Su: School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University
Yunbo Qiao: Precise Genome Engineering Center, School of Life Sciences, Guangzhou University

DOI: https://doi.org/10.1038/s41467-021-24813-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

The role of regulatory cis-elements in carcinogenesis and metastasis in esophageal squamous cell carcinoma remains crucial. Here the authors investigate H3K27ac-marked active enhancer profiles and transcriptomes in different types of esophageal tissues and identify oncogenic events and potential therapeutic targets.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal