Nature Communications (Dec 2022)
TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage
- Na Tang,
- Wen Tian,
- Guang-Yuan Ma,
- Xiong Xiao,
- Lei Zhou,
- Ze-Zhi Li,
- Xiao-Xiao Liu,
- Chong-Yao Li,
- Ke-Han Wu,
- Wenjuan Liu,
- Xue-Ying Wang,
- Yuan-Yuan Gao,
- Xin Yang,
- Jianzhao Qi,
- Ding Li,
- Yang Liu,
- Wen-Sheng Chen,
- Jinming Gao,
- Xiao-Qiang Li,
- Wei Cao
Affiliations
- Na Tang
- Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University
- Wen Tian
- Department of Pharmacology, School of Pharmacy, Fourth Military Medical University
- Guang-Yuan Ma
- Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University
- Xiong Xiao
- Department of Pharmacology, School of Pharmacy, Fourth Military Medical University
- Lei Zhou
- Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University
- Ze-Zhi Li
- Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University
- Xiao-Xiao Liu
- Department of Pharmacology, School of Pharmacy, Fourth Military Medical University
- Chong-Yao Li
- Department of Pharmacy, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University
- Ke-Han Wu
- Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University
- Wenjuan Liu
- Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University
- Xue-Ying Wang
- Department of Pharmacology, School of Pharmacy, Fourth Military Medical University
- Yuan-Yuan Gao
- Department of Pharmacology, School of Pharmacy, Fourth Military Medical University
- Xin Yang
- Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University
- Jianzhao Qi
- Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University
- Ding Li
- Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University
- Yang Liu
- Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University
- Wen-Sheng Chen
- Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University
- Jinming Gao
- Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University
- Xiao-Qiang Li
- Department of Pharmacology, School of Pharmacy, Fourth Military Medical University
- Wei Cao
- Department of Pharmacy, School of Chemistry & Pharmacy, Northwest A&F University
- DOI
- https://doi.org/10.1038/s41467-022-35242-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
TRPCs, nonselective cation channels, are involved in cardiac contraction and conduction. Here, the authors show that Trpc1/6 deficiency or pharmacological inhibition improves endotoxemic cardiac dysfunction and prolongs survival by prominently suppressing cardiac inflammation and ER Ca2+ release.
