Sensing of HIV-1 by TLR8 activates human T cells and reverses latency

Hany Zekaria Meås; Markus Haug; Marianne Sandvold Beckwith; Claire Louet; Liv Ryan; Zhenyi Hu; Johannes Landskron; Svein Arne Nordbø; Kjetil Taskén; Hang Yin; Jan Kristian Damås; Trude Helen Flo

doi:10.1038/s41467-019-13837-4

Nature Communications (Jan 2020)

Sensing of HIV-1 by TLR8 activates human T cells and reverses latency

Hany Zekaria Meås,
Markus Haug,
Marianne Sandvold Beckwith,
Claire Louet,
Liv Ryan,
Zhenyi Hu,
Johannes Landskron,
Svein Arne Nordbø,
Kjetil Taskén,
Hang Yin,
Jan Kristian Damås,
Trude Helen Flo

Affiliations

Hany Zekaria Meås: Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Markus Haug: Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Marianne Sandvold Beckwith: Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Claire Louet: Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Liv Ryan: Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Zhenyi Hu: School of Pharmaceutical Sciences, Tsinghua University—Peking University Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University
Johannes Landskron: Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital
Svein Arne Nordbø: Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Kjetil Taskén: Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital
Hang Yin: School of Pharmaceutical Sciences, Tsinghua University—Peking University Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University
Jan Kristian Damås: Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Trude Helen Flo: Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology

DOI: https://doi.org/10.1038/s41467-019-13837-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Manipulation of Toll-like receptors (TLRs) affects HIV-1 infection and latency reversal. Here, the authors show that HIV-1 is endocytosed and recognized by TLR8 in human primary CD4+T cells and that TLR8 stimulation induces an inflammatory response that promotes HIV-1 replication and reversal of latency.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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