Nature Communications (Nov 2020)

Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides

  • Anlian Zhu,
  • Xin Li,
  • Lili Bai,
  • Gongming Zhu,
  • Yuanyang Guo,
  • Jianwei Lin,
  • Yiwen Cui,
  • Gaofei Tian,
  • Lihe Zhang,
  • Jianji Wang,
  • Xiang David Li,
  • Lingjun Li

DOI
https://doi.org/10.1038/s41467-020-19409-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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ADP-ribosylated peptides are important molecular tools, however, the lack of effective synthetic methods hinders the access to their complex structures. Here, the authors present a biomimetic α-selective ribosylation reaction coupled with click chemistry ultimately providing a two-step modular synthesis of α-ADP-ribosylated peptides.