Nature Communications (Oct 2023)
Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation
- Adrien Robin,
- Angelique Van Ombergen,
- Claire Laurens,
- Audrey Bergouignan,
- Laurence Vico,
- Marie-Thérèse Linossier,
- Anne Pavy-Le Traon,
- Marc Kermorgant,
- Angèle Chopard,
- Guillaume Py,
- David Andrew Green,
- Michael Tipton,
- Alexander Choukér,
- Pierre Denise,
- Hervé Normand,
- Stéphane Blanc,
- Chantal Simon,
- Elisabeth Rosnet,
- Françoise Larcher,
- Peter Fernandez,
- Isabelle de Glisezinski,
- Dominique Larrouy,
- Isabelle Harant-Farrugia,
- Inês Antunes,
- Guillemette Gauquelin-Koch,
- Marie-Pierre Bareille,
- Rebecca Billette De Villemeur,
- Marc-Antoine Custaud,
- Nastassia Navasiolava
Affiliations
- Adrien Robin
- Univ Angers, CRC, CHU Angers, Inserm, CNRS, MITOVASC, Equipe CARME, SFR ICAT
- Angelique Van Ombergen
- European Space Agency (ESA)
- Claire Laurens
- Institute of Metabolic and Cardiovascular Diseases, INSERM, Paul Sabatier University
- Audrey Bergouignan
- Anschutz Health and Wellness Center, Division of Endocrinology, University of Colorado
- Laurence Vico
- INSERM, University Jean Monnet, Mines Saint-Etienne
- Marie-Thérèse Linossier
- INSERM, University Jean Monnet, Mines Saint-Etienne
- Anne Pavy-Le Traon
- Department of Neurology, CHU Toulouse and I2MC-INSERM 1297
- Marc Kermorgant
- Department of Neurology, CHU Toulouse and I2MC-INSERM 1297
- Angèle Chopard
- DMEM, Montpellier University, INRAE
- Guillaume Py
- DMEM, Montpellier University, INRAE
- David Andrew Green
- Centre of Human and Applied Physiological Sciences, King’s College London
- Michael Tipton
- Extreme Environments Laboratory, School of Sport, Health and Exercise Science, University of Portsmouth
- Alexander Choukér
- Laboratory of Translational Research Stress and Immunity, Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University (LUM)
- Pierre Denise
- Université de Caen Normandie, Inserm, COMETE U1075, CYCERON, CHU de Caen
- Hervé Normand
- Université de Caen Normandie, Inserm, COMETE U1075, CYCERON, CHU de Caen
- Stéphane Blanc
- DEPE-IPHC - Département Ecologie, Physiologie et Ethologie
- Chantal Simon
- CarMeN Laboratory, INSERM 1060, INRA 1397, University Claude Bernard Lyon1, Human Nutrition Research Center Rhône-Alpes
- Elisabeth Rosnet
- Faculty of Sport Sciences, Université de Reims Champagne-Ardenne
- Françoise Larcher
- Laboratoire de Biochimie, CHU d’Angers
- Peter Fernandez
- INSERM, University Jean Monnet, Mines Saint-Etienne
- Isabelle de Glisezinski
- Institute of Metabolic and Cardiovascular Diseases, INSERM, Paul Sabatier University
- Dominique Larrouy
- Institute of Metabolic and Cardiovascular Diseases, INSERM, Paul Sabatier University
- Isabelle Harant-Farrugia
- Institute of Metabolic and Cardiovascular Diseases, INSERM, Paul Sabatier University
- Inês Antunes
- Telespazio Belgium S.R.L. for the European Space Agency
- Guillemette Gauquelin-Koch
- Centre National d’Études Spatiales (CNES)
- Marie-Pierre Bareille
- Institute of Space Physiology and Medicine (MEDES)
- Rebecca Billette De Villemeur
- Institute of Space Physiology and Medicine (MEDES)
- Marc-Antoine Custaud
- Univ Angers, CRC, CHU Angers, Inserm, CNRS, MITOVASC, Equipe CARME, SFR ICAT
- Nastassia Navasiolava
- Univ Angers, CRC, CHU Angers, Inserm, CNRS, MITOVASC, Equipe CARME, SFR ICAT
- DOI
- https://doi.org/10.1038/s41467-023-41990-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
Abstract Astronauts in microgravity experience multi-system deconditioning, impacting their inflight efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of knowledge in the health impact of spaceflights, we simulate microgravity with a 5-day dry immersion in 18 healthy women (ClinicalTrials.gov Identifier: NCT05043974). Here we show that dry immersion rapidly induces a sedentarily-like metabolism shift mimicking the beginning of a metabolic syndrome with a drop in glucose tolerance, an increase in the atherogenic index of plasma, and an impaired lipid profile. Bone remodeling markers suggest a decreased bone formation coupled with an increased bone resorption. Fluid shifts and muscular unloading participate to a marked cardiovascular and sensorimotor deconditioning with decreased orthostatic tolerance, aerobic capacity, and postural balance. Collected datasets provide a comprehensive multi-systemic assessment of dry immersion effects in women and pave the way for future sex-based evaluations of countermeasures.
