mSystems (Aug 2021)

Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics

  • Orna Ernst,
  • Mohd M. Khan,
  • Benjamin L. Oyler,
  • Sung Hwan Yoon,
  • Jing Sun,
  • Fang-Yu Lin,
  • Nathan P. Manes,
  • Alexander D. MacKerell,
  • Iain D. C. Fraser,
  • Robert K. Ernst,
  • David R. Goodlett,
  • Aleksandra Nita-Lazar

DOI
https://doi.org/10.1128/mSystems.00306-21
Journal volume & issue
Vol. 6, no. 4

Abstract

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Macrophages and monocytes are innate immune cells playing an important role in orchestrating the initial innate immune response to bacterial infection and the tissue damage. This response is facilitated by specific receptors on the cell surface and intracellularly.