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Distribution of high and low risk HPV types by cytological status: a population based study from Italy

Infectious Agents and Cancer. 2011;6(1):2 DOI 10.1186/1750-9378-6-2


Journal Homepage

Journal Title: Infectious Agents and Cancer

ISSN: 1750-9378 (Online)

Publisher: BMC

Society/Institution: African Organization for Research and Training on Cancer (AORTIC)

LCC Subject Category: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens | Medicine: Internal medicine: Infectious and parasitic diseases

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB



Pini Maria T

Macis Rosalba

Scalisi Aurora

Angeloni Claudio

Lattanzi Amedeo

Carillo Giuseppe

Burroni Elena

Bisanzi Simonetta

Chini Francesco

Giorgi Rossi Paolo

Capparucci Paola

Guasticchi Gabriella

Carozzi Francesca M


Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 17 weeks


Abstract | Full Text

<p>Abstract</p> <p>Background</p> <p>HPV type distribution by cytological status represents useful information to predict the impact of mass vaccination on screening programs.</p> <p>Methods</p> <p>women aged from 25 to 64 who attended cervical cancer screening in five different Italian regions were tested for HPV infection with Hybrid Capture II (HCII) low and high risk probes. Women repeating Pap-test upon unsatisfactory or positive results, or as a post-treatment and post-colposcopy follow-up analysis, were excluded from our study. High risk (HR) HPV positive samples were typed using GP5+/GP6+ primed PCR, followed by Reverse Line Blot for 18 high/intermediate risk HPV types, while low risk (LR) HPV positive samples were tested with type specific primers for HPV6 and HPV11.</p> <p>Results</p> <p>3410 women had a valid HCII and Pap-test. The prevalence of HR and LR infections was 7.0% and 3.6%, 29.1% and 13.7%, 68.1% and 31.9%, 60.0% and 0.0%, 65.0% and 12.0%, for negative, ASC-US, L-SIL, ASC-H and H-SIL cytology, respectively. The fraction of ASC-US+ cytology due to HPV 16 and 18 ranged from 11.2 (HPV 16/18 alone) to 15.4% (including HPV 16/18 in co-infection with other virus strains), and that due to HPV 6 and 11 ranged from 0.2% (HPV 6/11 alone) to 0.7% (including HPV 6/11 in co-infection with other LR virus strains).</p> <p>Conclusions</p> <p>mass vaccination with bivalent or quadrivalent HPV vaccine would modestly impact on prevalence of abnormal Pap-test in screening.</p>