Nature Communications (Nov 2021)
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
- Thomas Kruse,
- Caroline Benz,
- Dimitriya H. Garvanska,
- Richard Lindqvist,
- Filip Mihalic,
- Fabian Coscia,
- Raviteja Inturi,
- Ahmed Sayadi,
- Leandro Simonetti,
- Emma Nilsson,
- Muhammad Ali,
- Johanna Kliche,
- Ainhoa Moliner Morro,
- Andreas Mund,
- Eva Andersson,
- Gerald McInerney,
- Matthias Mann,
- Per Jemth,
- Norman E. Davey,
- Anna K. Överby,
- Jakob Nilsson,
- Ylva Ivarsson
Affiliations
- Thomas Kruse
- The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
- Caroline Benz
- Department of Chemistry - BMC, Uppsala University
- Dimitriya H. Garvanska
- The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
- Richard Lindqvist
- Department of Clinical Microbiology, Umeå University
- Filip Mihalic
- Department of Medical Biochemistry and Microbiology, Uppsala University
- Fabian Coscia
- The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
- Raviteja Inturi
- Department of Medical Biochemistry and Microbiology, Uppsala University
- Ahmed Sayadi
- Department of Chemistry - BMC, Uppsala University
- Leandro Simonetti
- Department of Chemistry - BMC, Uppsala University
- Emma Nilsson
- Department of Clinical Microbiology, Umeå University
- Muhammad Ali
- Department of Chemistry - BMC, Uppsala University
- Johanna Kliche
- Department of Chemistry - BMC, Uppsala University
- Ainhoa Moliner Morro
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet
- Andreas Mund
- The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
- Eva Andersson
- Department of Medical Biochemistry and Microbiology, Uppsala University
- Gerald McInerney
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet
- Matthias Mann
- The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
- Per Jemth
- Department of Medical Biochemistry and Microbiology, Uppsala University
- Norman E. Davey
- Division of Cancer Biology, The Institute of Cancer Research
- Anna K. Överby
- Department of Clinical Microbiology, Umeå University
- Jakob Nilsson
- The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
- Ylva Ivarsson
- Department of Chemistry - BMC, Uppsala University
- DOI
- https://doi.org/10.1038/s41467-021-26498-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Many interactions between viral and host proteins are mediated by short peptide motifs. Here, using a phage-based viral peptide library, the authors identify 269 peptide-based interactions for 18 coronaviruses, including an interaction between SARS-CoV-2 N and G3BP1/2 that affects stress granules.
