NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ

Jianfeng Huang; Juan F. Linares; Angeles Duran; Wenmin Xia; Alan R. Saltiel; Timo D. Müller; Maria T. Diaz-Meco; Jorge Moscat

doi:10.1038/s41467-021-23085-0

Nature Communications (May 2021)

NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ

Jianfeng Huang,
Juan F. Linares,
Angeles Duran,
Wenmin Xia,
Alan R. Saltiel,
Timo D. Müller,
Maria T. Diaz-Meco,
Jorge Moscat

Affiliations

Jianfeng Huang: Sanford Burnham Prebys Medical Discovery Institute
Juan F. Linares: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
Angeles Duran: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
Wenmin Xia: Division of Metabolism and Endocrinology, Department of Medicine, University of California, San Diego
Alan R. Saltiel: Division of Metabolism and Endocrinology, Department of Medicine, University of California, San Diego
Timo D. Müller: Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Centre Munich
Maria T. Diaz-Meco: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
Jorge Moscat: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine

DOI: https://doi.org/10.1038/s41467-021-23085-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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p62 is a signaling hub protein that contributes to the control of energy expenditure. Here the authors investigate the relative roles of p62 and a similar protein, NBR1, and show that NBR1 is required for the repression of thermogenesis in adipocytes occurring in the absence of p62.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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