Effect of amifostine on sperm DNA fragmentation and testes after radioiodine treatment

Abstract

Introduction: Radioactive iodine (RAI) is commonly used for the treatment of hyperthyroidism caused by Graves’ disease or thyroid nodules. However, information available on the impact of RAI therapy on male gonadal function is scarce. This study aimed to determine any possible damage to testicular tissue and sperm quality caused by RAI therapy, and the radioprotective effect of amifostine against such damage.

Keywords

• testes
• radioiodine
• apoptosis
• amifostine
• sperm dna