Epi-illumination gradient light interference microscopy for imaging opaque structures

Mikhail E. Kandel; Chenfei Hu; Ghazal Naseri Kouzehgarani; Eunjung Min; Kathryn Michele Sullivan; Hyunjoon Kong; Jennifer M. Li; Drew N. Robson; Martha U. Gillette; Catherine Best-Popescu; Gabriel Popescu

doi:10.1038/s41467-019-12634-3

Nature Communications (Oct 2019)

Epi-illumination gradient light interference microscopy for imaging opaque structures

Mikhail E. Kandel,
Chenfei Hu,
Ghazal Naseri Kouzehgarani,
Eunjung Min,
Kathryn Michele Sullivan,
Hyunjoon Kong,
Jennifer M. Li,
Drew N. Robson,
Martha U. Gillette,
Catherine Best-Popescu,
Gabriel Popescu

Affiliations

Mikhail E. Kandel: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign
Chenfei Hu: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign
Ghazal Naseri Kouzehgarani: Beckman Institute, University of Illinois at Urbana-Champaign
Eunjung Min: Rowland Institute at Harvard University, Cambridge
Kathryn Michele Sullivan: Department of Bioengineering, University of Illinois at Urbana-Champaign
Hyunjoon Kong: Beckman Institute, University of Illinois at Urbana-Champaign
Jennifer M. Li: Rowland Institute at Harvard University, Cambridge
Drew N. Robson: Rowland Institute at Harvard University, Cambridge
Martha U. Gillette: Beckman Institute, University of Illinois at Urbana-Champaign
Catherine Best-Popescu: Beckman Institute, University of Illinois at Urbana-Champaign
Gabriel Popescu: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign

DOI: https://doi.org/10.1038/s41467-019-12634-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Quantitative phase imaging techniques have been limited by multiple scattering of light or its use in transmission mode. Here, the authors show a gradient light interference microscopy method in a reflection geometry which allows for label-free phase imaging of bulk and opaque samples.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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