The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes

Tobias Ritterhoff; Hrishikesh Das; Götz Hofhaus; Rasmus R. Schröder; Annette Flotho; Frauke Melchior

doi:10.1038/ncomms11482

Nature Communications (May 2016)

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes

Tobias Ritterhoff,
Hrishikesh Das,
Götz Hofhaus,
Rasmus R. Schröder,
Annette Flotho,
Frauke Melchior

Affiliations

Tobias Ritterhoff: Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance
Hrishikesh Das: Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance
Götz Hofhaus: Cryo Electron Microscopy, CellNetworks, BioQuant, Universitätsklinikum Heidelberg
Rasmus R. Schröder: Cryo Electron Microscopy, CellNetworks, BioQuant, Universitätsklinikum Heidelberg
Annette Flotho: Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance
Frauke Melchior: Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance

DOI: https://doi.org/10.1038/ncomms11482
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Continuous cycles of nucleo-cytoplasmic transport require disassembly of transport receptor-Ran-GTP complexes in the cytoplasm. Here the authors elucidate the specific function of the RanBP2 complex in the disassembly process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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