Frontiers in Neuroscience (May 2022)
MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis
- Marcela Alvia,
- Nurgul Aytan,
- Nurgul Aytan,
- Keith R. Spencer,
- Zachariah W. Foster,
- Nazifa Abdul Rauf,
- Latease Guilderson,
- Ian Robey,
- James G. Averill,
- Sean E. Walker,
- Victor E. Alvarez,
- Victor E. Alvarez,
- Victor E. Alvarez,
- Victor E. Alvarez,
- Bertrand R. Huber,
- Bertrand R. Huber,
- Bertrand R. Huber,
- Rebecca Mathais,
- Kerry A. Cormier,
- Kerry A. Cormier,
- Kerry A. Cormier,
- Raymond Nicks,
- Morgan Pothast,
- Adam Labadorf,
- Adam Labadorf,
- Filisia Agus,
- Michael L. Alosco,
- Michael L. Alosco,
- Jesse Mez,
- Jesse Mez,
- Neil W. Kowall,
- Neil W. Kowall,
- Neil W. Kowall,
- Ann C. McKee,
- Ann C. McKee,
- Ann C. McKee,
- Ann C. McKee,
- Ann C. McKee,
- Christopher B. Brady,
- Christopher B. Brady,
- Christopher B. Brady,
- Thor D. Stein,
- Thor D. Stein,
- Thor D. Stein,
- Thor D. Stein
Affiliations
- Marcela Alvia
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Nurgul Aytan
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Nurgul Aytan
- Department of Neurology, Boston University School of Medicine, Boston, MA, United States
- Keith R. Spencer
- VA Boston Healthcare System, Boston, MA, United States
- Zachariah W. Foster
- VA Boston Healthcare System, Boston, MA, United States
- Nazifa Abdul Rauf
- VA Boston Healthcare System, Boston, MA, United States
- Latease Guilderson
- VA Boston Healthcare System, Boston, MA, United States
- Ian Robey
- Southern Arizona VA Healthcare System, Tucson, AZ, United States
- James G. Averill
- Southern Arizona VA Healthcare System, Tucson, AZ, United States
- Sean E. Walker
- Southern Arizona VA Healthcare System, Tucson, AZ, United States
- Victor E. Alvarez
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Victor E. Alvarez
- Department of Neurology, Boston University School of Medicine, Boston, MA, United States
- Victor E. Alvarez
- VA Boston Healthcare System, Boston, MA, United States
- Victor E. Alvarez
- Department of Veterans Affairs Medical Center, Bedford, MA, United States
- Bertrand R. Huber
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Bertrand R. Huber
- Department of Neurology, Boston University School of Medicine, Boston, MA, United States
- Bertrand R. Huber
- VA Boston Healthcare System, Boston, MA, United States
- Rebecca Mathais
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Kerry A. Cormier
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Kerry A. Cormier
- VA Boston Healthcare System, Boston, MA, United States
- Kerry A. Cormier
- Department of Veterans Affairs Medical Center, Bedford, MA, United States
- Raymond Nicks
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Morgan Pothast
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Adam Labadorf
- Department of Neurology, Boston University School of Medicine, Boston, MA, United States
- Adam Labadorf
- VA Boston Healthcare System, Boston, MA, United States
- Filisia Agus
- Department of Neurology, Boston University School of Medicine, Boston, MA, United States
- Michael L. Alosco
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Michael L. Alosco
- Department of Neurology, Boston University School of Medicine, Boston, MA, United States
- Jesse Mez
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Jesse Mez
- Department of Neurology, Boston University School of Medicine, Boston, MA, United States
- Neil W. Kowall
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Neil W. Kowall
- Department of Neurology, Boston University School of Medicine, Boston, MA, United States
- Neil W. Kowall
- VA Boston Healthcare System, Boston, MA, United States
- Ann C. McKee
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Ann C. McKee
- Department of Neurology, Boston University School of Medicine, Boston, MA, United States
- Ann C. McKee
- VA Boston Healthcare System, Boston, MA, United States
- Ann C. McKee
- Department of Veterans Affairs Medical Center, Bedford, MA, United States
- Ann C. McKee
- Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, United States
- Christopher B. Brady
- Department of Neurology, Boston University School of Medicine, Boston, MA, United States
- Christopher B. Brady
- VA Boston Healthcare System, Boston, MA, United States
- Christopher B. Brady
- Department of Veterans Affairs Medical Center, Bedford, MA, United States
- Thor D. Stein
- Boston University Alzheimer’s Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, MA, United States
- Thor D. Stein
- VA Boston Healthcare System, Boston, MA, United States
- Thor D. Stein
- Department of Veterans Affairs Medical Center, Bedford, MA, United States
- Thor D. Stein
- Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, United States
- DOI
- https://doi.org/10.3389/fnins.2022.855096
- Journal volume & issue
-
Vol. 16
Abstract
Repetitive head impacts (RHI) and traumatic brain injuries are risk factors for the neurodegenerative diseases chronic traumatic encephalopathy (CTE) and amyotrophic lateral sclerosis (ALS). ALS and CTE are distinct disorders, yet in some instances, share pathology, affect similar brain regions, and occur together. The pathways involved and biomarkers for diagnosis of both diseases are largely unknown. MicroRNAs (miRNAs) involved in gene regulation may be altered in neurodegeneration and be useful as stable biomarkers. Thus, we set out to determine associations between miRNA levels and disease state within the prefrontal cortex in a group of brain donors with CTE, ALS, CTE + ALS and controls. Of 47 miRNAs previously implicated in neurological disease and tested here, 28 (60%) were significantly different between pathology groups. Of these, 21 (75%) were upregulated in both ALS and CTE, including miRNAs involved in inflammatory, apoptotic, and cell growth/differentiation pathways. The most significant change occurred in miR-10b, which was significantly increased in ALS, but not CTE or CTE + ALS. Overall, we found patterns of miRNA expression that are common and unique to CTE and ALS and that suggest shared and distinct mechanisms of pathogenesis.
Keywords