Recent Advances in Phage-Based Therapeutics for Multi-Drug Resistant <em>Acinetobacter baumannii</em>

Abstract

Acinetobacter baumannii is an important opportunistic pathogen common in clinical infections. Phage therapy become a hot research field worldwide again after the post-antibiotic era. This review summarizes the important progress of phage treatments for A. baumannii in the last five years, and focus on the new interesting advances including the combination of phage and other substances (like photosensitizer), and the phage encapsulation (by microparticle, hydrogel) in delivery. We also discuss the remaining challenges and promising directions for phage-based therapy of A. baumannii infection in the future, and the innovative combination of materials in this area may be one promising direction.

Keywords

• <i>Acinetobacter baumannii</i>
• phage
• endolysin
• depolymerase
• encapsulation
• delivery