Nature Communications (Nov 2016)

Vasculogenic mimicry in small cell lung cancer

  • Stuart C. Williamson,
  • Robert L. Metcalf,
  • Francesca Trapani,
  • Sumitra Mohan,
  • Jenny Antonello,
  • Benjamin Abbott,
  • Hui Sun Leong,
  • Christopher P. E. Chester,
  • Nicole Simms,
  • Radoslaw Polanski,
  • Daisuke Nonaka,
  • Lynsey Priest,
  • Alberto Fusi,
  • Fredrika Carlsson,
  • Anders Carlsson,
  • Mary J. C. Hendrix,
  • Richard E. B. Seftor,
  • Elisabeth A. Seftor,
  • Dominic G. Rothwell,
  • Andrew Hughes,
  • James Hicks,
  • Crispin Miller,
  • Peter Kuhn,
  • Ged Brady,
  • Kathryn L. Simpson,
  • Fiona H. Blackhall,
  • Caroline Dive

DOI
https://doi.org/10.1038/ncomms13322
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Small cell lung cancer (SCLC) is characterised by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. The authors show that SCLC patients have a rare CTC subset with a vasculogenic mimicry (VM) phenotype, and that VM is associated with worse overall survival, and alters tumour growth, chemotherapy delivery and efficacy.