Life (Feb 2023)

Positioning Transclival Tumor-Treating Fields for the Treatment of Diffuse Intrinsic Pontine Gliomas

  • Walid Ibn Essayed,
  • Casey A. Jarvis,
  • Joshua D. Bernstock,
  • Anna Slingerland,
  • John Albanese,
  • Gregory K. Friedman,
  • Omar Arnaout,
  • Lissa Baird

DOI
https://doi.org/10.3390/life13030601
Journal volume & issue
Vol. 13, no. 3
p. 601

Abstract

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Diffuse intrinsic pontine glioma (DIPG) carries an extremely poor prognosis, with 2-year survival rates of 2 = 0.568, p = 0.005 *; R2 = 0.605, p = 0.0002 *). Critically, neither of these parameters represent limitations to the implantation of a device within the dimensions of those currently available. Our findings confirm that the anatomy present within this age group is amenable to the placement of a 2 × 1 cm electrode array in 94% of patients examined. Our work serves to demonstrate the feasibility of implantable transclival devices for the provision of TTFs as a novel adjunctive therapy for DIPG.

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