Pharmaciana (Nov 2011)
OPTIMASI KOMPOSISI TEPUNG BERAS DAN FRAKSI ETANOL DAUN SENDOK (Plantago major, L) DALAM FORMULASI TABIR SURYA DENGAN METODE SIMPLEX LATTICE DESIGN
Abstract
Octyl methoxycinnamate is an active ingredient in sunscreen that will be degradated after exposure by sunlight. On the other hand, antioxidants have potential capability as photoprotector which in this study is used the ethanol fraction of leaf of Plantago major, L to support activity of OMS. In addition, rice flour is added too because it has the ability to reflect sunlight. The aim of this study is to obtain the optimum composition of them, based on the effectivity of OMS. This study used three formulas based on the simplex lattice design method with a comparison of octyl methoxycinnamate and rice flour as follows: FI (100%: 0%), the formula II (50%: 50%), formula III (0%: 100%). All formulas were exposured by sunlight for 5 hours (at 09:00 to 14:00 GMT) and in interval one hour samples were taken to measure the value of % erythema transmission (% Te) and pigmentation (% Tp). Data were analysed to get the optimum composition which has the highest of response. The results showed that 100% rice flour was the optimum addition to support activity of OMS as sunscreen with decreasing of % erythema transmission and pigmentation was 200%, 75%, respectively.
Keywords
