Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity
Raúl Colorado-Peralta,
José Luis Olivares-Romero,
Sharon Rosete-Luna,
Oscar García-Barradas,
Viviana Reyes-Márquez,
Delia Hernández-Romero,
David Morales-Morales
Affiliations
Raúl Colorado-Peralta
Facultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P. 94340, Veracruz, Mexico
José Luis Olivares-Romero
Instituto de Ecología A.C., Red de Estudios Moleculares Avanzados, Clúster Científico y Tecnológico BioMimic<sup>®</sup>, Carretera Antigua a Coatepec, No. 351, Xalapa C.P. 91070, Veracruz, Mexico
Sharon Rosete-Luna
Facultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P. 94340, Veracruz, Mexico
Oscar García-Barradas
Instituto de Química Aplicada, Universidad Veracruzana, Luis Castelazo Ayala S/N, Xalapa C.P. 91190, Veracruz, Mexico
Viviana Reyes-Márquez
Departamento de Ciencias Químico-Biológicas, Universidad de Sonora, Luis Encinas y Rosales S/N, Hermosillo C.P. 83000, Sonora, Mexico
Delia Hernández-Romero
Facultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P. 94340, Veracruz, Mexico
David Morales-Morales
Instituto de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Circuito Exterior S/N, Coyoacán C.P. 04510, Ciudad de México, Mexico
Throughout human history, bacteria and fungi have caused infections that are difficult to combat. For this reason, countless research groups have developed novel compounds to solve this problem. Thiazole and benzothiazole are present in different structures with interesting biological effects and are used to develop new effective antimicrobial agents. Moreover, nitrogen atoms that are present in this heterocycle allow for coordination with various metals, forming metal complexes that enhance the biological activity of organic ligands that are often used as commercial drugs. This bibliographical review summarizes the copper complexes that use thiazole and benzothiazole as ligands and that report efficient antimicrobial activity against different bacteria and fungi.
