Aggressive Natural Killer Cell Leukemia in an Adolescent Patient: A Case Report and Literature Review

Rong Yang; Rong Yang; Yuan Ai; Yuan Ai; Chuan Liu; Chuan Liu; Xiaoxi Lu; Xiaoxi Lu

doi:10.3389/fped.2022.829927

Frontiers in Pediatrics (May 2022)

Aggressive Natural Killer Cell Leukemia in an Adolescent Patient: A Case Report and Literature Review

Rong Yang,
Rong Yang,
Yuan Ai,
Yuan Ai,
Chuan Liu,
Chuan Liu,
Xiaoxi Lu,
Xiaoxi Lu

Affiliations

Rong Yang: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Rong Yang: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Yuan Ai: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Yuan Ai: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Chuan Liu: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Chuan Liu: Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China
Xiaoxi Lu: Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Xiaoxi Lu: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China

DOI: https://doi.org/10.3389/fped.2022.829927
Journal volume & issue: Vol. 10

Abstract

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Aggressive natural killer cell leukemia (ANKL) is a rare malignant tumor, especially uncommon in children. ANKL has very aggressive clinical course and bad prognosis and is usually caused by Epstein-Barr virus infection. ANKL often has clinical manifestations of hemophagocytic lymphohistiocytosis (HLH) and can be easily treated as HLH, which might complicate this aggressive disease. Here we report an ANKL in adolescent whose clinical presentation was highly aggressive and response to L-asparaginase containing chemotherapy was very bad. Early-onset Flow cytometry of peripheral blood and bone marrow help make the diagnosis.

Published in Frontiers in Pediatrics

ISSN: 2296-2360 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://journal.frontiersin.org/journal/pediatrics

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