Nature Communications (Mar 2021)
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression
- Eilam Yeini,
- Paula Ofek,
- Sabina Pozzi,
- Nitzan Albeck,
- Dikla Ben-Shushan,
- Galia Tiram,
- Sapir Golan,
- Ron Kleiner,
- Ron Sheinin,
- Sahar Israeli Dangoor,
- Shlomit Reich-Zeliger,
- Rachel Grossman,
- Zvi Ram,
- Henry Brem,
- Thomas M. Hyde,
- Prerna Magod,
- Dinorah Friedmann-Morvinski,
- Asaf Madi,
- Ronit Satchi-Fainaro
Affiliations
- Eilam Yeini
- Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University
- Paula Ofek
- Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University
- Sabina Pozzi
- Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University
- Nitzan Albeck
- Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University
- Dikla Ben-Shushan
- Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University
- Galia Tiram
- Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University
- Sapir Golan
- Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University
- Ron Kleiner
- Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University
- Ron Sheinin
- Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University
- Sahar Israeli Dangoor
- Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University
- Shlomit Reich-Zeliger
- Department of Immunology, Weizmann Institute of Science
- Rachel Grossman
- Department of Neurosurgery, Tel Aviv Sourasky Medical Center
- Zvi Ram
- Department of Neurosurgery, Tel Aviv Sourasky Medical Center
- Henry Brem
- Department of Neurosurgery, Johns Hopkins University School of Medicine
- Thomas M. Hyde
- Lieber Institute for Brain Development, Johns Hopkins Medical Campus
- Prerna Magod
- Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Sherman Building, Tel Aviv University
- Dinorah Friedmann-Morvinski
- Sagol School of Neurosciences, Tel Aviv University
- Asaf Madi
- Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University
- Ronit Satchi-Fainaro
- Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University
- DOI
- https://doi.org/10.1038/s41467-021-22186-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
Glioma-associated microglia/macrophages are central drivers of brain tumor pathology. Here the authors characterize the role of the P-selectin/PSGL-1 axis in the cross-talk between glioblastoma cells and microglia/macrophages and show that the therapeutic targeting of P-selectin limits glioblastoma progression in preclinical models.
