Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality
Sachiko Seo,
Alpana Waghmare,
Emily M Scott,
Hu Xie,
Jane M Kuypers,
Robert C. Hackman,
Angela P. Campbell,
Su-Mi Choi,
Wendy M. Leisenring,
Keith R. Jerome,
Janet A. Englund,
Michael Boeckh
Affiliations
Sachiko Seo
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Department of Hematology and Oncology, National Cancer Research Center East, Chiba, Japan
Alpana Waghmare
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Department of Pediatrics, University of Washington, Seattle, WA, USA;Pediatric Infectious Disease Division, Seattle Children’s Hospital, WA, USA
Emily M Scott
School of Medicine, University of Washington, Seattle, WA, USA
Hu Xie
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Jane M Kuypers
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
Robert C. Hackman
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Angela P. Campbell
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Department of Pediatrics, University of Washington, Seattle, WA, USA;Pediatric Infectious Disease Division, Seattle Children’s Hospital, WA, USA
Su-Mi Choi
Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
Wendy M. Leisenring
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Keith R. Jerome
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
Janet A. Englund
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Department of Pediatrics, University of Washington, Seattle, WA, USA;Pediatric Infectious Disease Division, Seattle Children’s Hospital, WA, USA
Michael Boeckh
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Department of Medicine, University of Washington, Seattle, WA, USA
Human rhinoviruses are the most common respiratory viruses detected in patients after hematopoietic cell transplantation. Although rhinovirus appears to occasionally cause severe lower respiratory tract infection in immunocompromised patients, the clinical significance of rhinovirus detection in the lower respiratory tract remains unknown. We evaluated 697 recipients transplanted between 1993 and 2015 with rhinovirus in respiratory samples. As comparative cohorts, 273 recipients with lower respiratory tract infection caused by respiratory syncytial virus (N=117), parainfluenza virus (N=120), or influenza (N=36) were analyzed. Factors associated with mortality were analyzed using Cox proportional hazard models. Among 569 subjects with rhinovirus upper respiratory tract infection and 128 subjects with rhinovirus lower respiratory tract infection, probabilities of overall mortality at 90 days were 6% and 41%, respectively (P
