Nature Communications (Apr 2022)
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
- Chao Wang,
- Li Fan,
- Rabia R. Khawaja,
- Bangyan Liu,
- Lihong Zhan,
- Lay Kodama,
- Marcus Chin,
- Yaqiao Li,
- David Le,
- Yungui Zhou,
- Carlo Condello,
- Lea T. Grinberg,
- William W. Seeley,
- Bruce L. Miller,
- Sue-Ann Mok,
- Jason E. Gestwicki,
- Ana Maria Cuervo,
- Wenjie Luo,
- Li Gan
Affiliations
- Chao Wang
- Gladstone Institutes, University of California, San Francisco
- Li Fan
- Helen and Robert Appel Alzheimer’s Disease Institute, Brain and Mind Research Institute, Weill Cornell Medicine
- Rabia R. Khawaja
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Bangyan Liu
- Helen and Robert Appel Alzheimer’s Disease Institute, Brain and Mind Research Institute, Weill Cornell Medicine
- Lihong Zhan
- Gladstone Institutes, University of California, San Francisco
- Lay Kodama
- Helen and Robert Appel Alzheimer’s Disease Institute, Brain and Mind Research Institute, Weill Cornell Medicine
- Marcus Chin
- Gladstone Institutes, University of California, San Francisco
- Yaqiao Li
- Gladstone Institutes, University of California, San Francisco
- David Le
- Gladstone Institutes, University of California, San Francisco
- Yungui Zhou
- Gladstone Institutes, University of California, San Francisco
- Carlo Condello
- Institute for Neurodegenerative Diseases, University of California, San Francisco
- Lea T. Grinberg
- Department of Neurology, University of California, San Francisco
- William W. Seeley
- Department of Neurology, University of California, San Francisco
- Bruce L. Miller
- Department of Neurology, University of California, San Francisco
- Sue-Ann Mok
- Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta
- Jason E. Gestwicki
- Institute for Neurodegenerative Diseases, University of California, San Francisco
- Ana Maria Cuervo
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Wenjie Luo
- Helen and Robert Appel Alzheimer’s Disease Institute, Brain and Mind Research Institute, Weill Cornell Medicine
- Li Gan
- Gladstone Institutes, University of California, San Francisco
- DOI
- https://doi.org/10.1038/s41467-022-29552-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Wang et al show that microglial NF-κB activation is essential for tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice. Inactivation of NF-κB reversed tau associated microglial states and rescued autophagy deficits.
