Assessing the influence of aneurysm dimensions on hemodynamic patterns and wall deformation dynamics for predicting rupture risk

Abstract

Cerebral aneurysms are among the most dangerous cardiovascular diseases which display no symptoms prior to reaching critical conditions. As cerebral aneurysms are deadly diseases with a very small treatment window after reaching the critical stage, numerical investigations of this phenomenon are commonly used to assess the risk of rupture. In this study, the fluid-structure interaction (FSI) method is used to analyze the effects of aneurysm size on hemodynamic factors predicting rupture in three aneurysms of different geometries, at the same location, and using the same boundary conditions. In the present study, the aneurysms experience TAWSS at values under 2 Pa in incremented areas as the aneurysmal sizes increase, this is while the relatively larger distribution of high TAWSS (as high as 20 Pa) regions are perceived in smaller aneurysms. Furthermore, the maximum OSI stands at below 0.05 in the smaller cases while the larger case experiences a maximum OSI as high as 0.2, which is considered a predictive parameter for rupture. The vortex core lines experience discontinuities with increased aneurysmal size, which is in agreement with the development of flow complexities with size. The hemodynamics factors such as the time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and vortex core line investigated in this study, suggest that greater size can be considered a major risk factor for rupture. In addition to that, we have found that the displacement trend of the aneurysm changes as size increases; developing more in the dome rather than the aneurysmal sac. This change in trend might also present a potential to be used as a predictive parameter.

Keywords

• Fluid-structure interaction
• Cerebral aneurysms
• Rupture prediction
• Hemodynamic factors