Antiaggregant therapy in neurological practice: objectives and possibilities

Abstract

Based on the data available in the literature, the authors consider the prevention of ischemic stroke and other cardiovascular diseases in high-risk group patients. Timely identification and assessment of risk factors in a specific patient allow one to elaborate individual and the most optimal management tactics and to define rational drug therapy. Antiplatelet therapy the efficiency of which has been confirmed during randomized clinical trials is pathogenetically warranted. The paper considers the preventive and therapeutic efficacy of different groups of anriaggregants, such as aspirin, thienopyridines, and dipyridamole. It also gives data on the use of surgical and X-ray techniques to prevent cerebral circulatory disorders.

Keywords

• ischemic stroke
• cardiovascular diseases
• prevention
• antiplatelet therapy
• aspirin
• clopidogrel
• ticlopidine
• sustained release dipyridamole
• carotid endarterectomy
• angioplasty
• stenting