Exploring the therapeutic potential of Saudi Kleinia anteuphorbium (L.) DC. Essential oil: Insights into antioxidant, analgesic, and hepatorenal protective effects

Abstract

Lately, the herb's essential oils have received the intense attention of researchers and pharmaceutical agencies. The chemical composition, antioxidant, analgesic activity, anti-hyperpyrexia, and hepatorenal protective effects of the Kleinia anteuphorbium (L.) DC. Essential oil (KAEO) were evaluated. The KAEO was yanked by steam distillation and subjected to a GC/MS system. The antioxidant powers of KAEO were evaluated by DPPH, NO, and FRAP tests. Besides the anti-hyperpyrexia, the analgesic effects were assessed. Moreover, the hepatorenal curative effects were evaluated in a carbon tetrachloride-rat model. Sixty-eight active components were identified by GC/MS. α-pinene was the most dominant monoterpene in KAEO. KAEO showed anti-hyperpyrexia, anti-captive, and great antioxidant powers through DPPH, NO, and FRAP. The oral LD50 of KAEO was 187.5 mg/kg in rats. Furthermore, KAEO treatment succeeded in reliving the adverse effects of CCL4 in rats as a standard toxic model through reliving the hepatic pathological and oxidative stress and restoring the hepatic and renal functions. Overall, the obtained results demonstrated that KAEO might be used as a potential natural medicine to relieve a variety of modern symptoms and hepatorenal disorders associated with oxidative stress.

Keywords

• Analgesic
• Carbon tetrachloride
• Essential oil
• Hepatorenal protection
• Hyperpyrexia
• Kleinia anteuphorbium