Nature Communications (Oct 2018)
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
- Sonya A. MacParland,
- Jeff C. Liu,
- Xue-Zhong Ma,
- Brendan T. Innes,
- Agata M. Bartczak,
- Blair K. Gage,
- Justin Manuel,
- Nicholas Khuu,
- Juan Echeverri,
- Ivan Linares,
- Rahul Gupta,
- Michael L. Cheng,
- Lewis Y. Liu,
- Damra Camat,
- Sai W. Chung,
- Rebecca K. Seliga,
- Zigong Shao,
- Elizabeth Lee,
- Shinichiro Ogawa,
- Mina Ogawa,
- Michael D. Wilson,
- Jason E. Fish,
- Markus Selzner,
- Anand Ghanekar,
- David Grant,
- Paul Greig,
- Gonzalo Sapisochin,
- Nazia Selzner,
- Neil Winegarden,
- Oyedele Adeyi,
- Gordon Keller,
- Gary D. Bader,
- Ian D. McGilvray
Affiliations
- Sonya A. MacParland
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Jeff C. Liu
- The Donnelly Centre, University of Toronto
- Xue-Zhong Ma
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Brendan T. Innes
- The Donnelly Centre, University of Toronto
- Agata M. Bartczak
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Blair K. Gage
- McEwen Centre for Regenerative Medicine, University Health Network
- Justin Manuel
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Nicholas Khuu
- Princess Margaret Genomics Centre, University Health Network
- Juan Echeverri
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Ivan Linares
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Rahul Gupta
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Michael L. Cheng
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Lewis Y. Liu
- Department of Immunology, University of Toronto
- Damra Camat
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Sai W. Chung
- Department of Immunology, University of Toronto
- Rebecca K. Seliga
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Zigong Shao
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Elizabeth Lee
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Shinichiro Ogawa
- McEwen Centre for Regenerative Medicine, University Health Network
- Mina Ogawa
- McEwen Centre for Regenerative Medicine, University Health Network
- Michael D. Wilson
- Department of Molecular Genetics, University of Toronto
- Jason E. Fish
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Markus Selzner
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Anand Ghanekar
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- David Grant
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Paul Greig
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Gonzalo Sapisochin
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Nazia Selzner
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Neil Winegarden
- Princess Margaret Genomics Centre, University Health Network
- Oyedele Adeyi
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- Gordon Keller
- McEwen Centre for Regenerative Medicine, University Health Network
- Gary D. Bader
- The Donnelly Centre, University of Toronto
- Ian D. McGilvray
- Multi-Organ Transplant Program, Toronto General Hospital Research Institute
- DOI
- https://doi.org/10.1038/s41467-018-06318-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 21
Abstract
The development of single cell RNA sequencing technologies has been instrumental in advancing our understanding of tissue biology. Here, MacParland et al. performed single cell RNA sequencing of human liver samples, and identify distinct populations of intrahepatic macrophages that may play specific roles in liver disease.
