Allogeneic ADSCs induce CD8 T cell-mediated cytotoxicity and faster cell death after exposure to xenogeneic serum or proinflammatory cytokines

Abstract

Stem cell therapy: Limiting immune response attacks The conditions under which donor stem cells are cultured can limit attack by the recipient’s immune system after transplantation. Adult stem cells taken from donors who are genetically similar to recipients show promise as therapeutic agents for various conditions, from cardiac to immunity-related diseases. However, patients’ immune systems will often attack and destroy the transplanted cells. Chung-Gyu Park and Sung-Ho Chang at Seoul National University, South Korea, explored methods of growing stem cells so that they are less likely to be destroyed by the patient’s T-cells. The team found that human T-cells will attack stem cells grown in media containing bovine serum or those pre-treated with pro-inflammatory proteins. T-cell activity was weaker against stem cells grown in media with autologous serum.