Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling

Abstract

The chromone scaffold is present in drugs and bioactive natural products, but conventional approaches to access chromones require stoichiometric amounts of oxidants. Here, the authors report rhodaelectro-catalyzed assembly of chromones by electrochemical formyl C–H activations, providing the basis for late-stage peptide diversification.