METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD

A. V. Baklykov; A. A. Tumashov; S. K. Kotovskaya; E. N. Ulomskiy; G. L. Rusinov; V. L. Rusinov; D. S. Kopchuk; O. N. Chupakhin; V. N. Charushin

Разработка и регистрация лекарственных средств (Jan 2019)

METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD

A. V. Baklykov,
A. A. Tumashov,
S. K. Kotovskaya,
E. N. Ulomskiy,
G. L. Rusinov,
V. L. Rusinov,
D. S. Kopchuk,
O. N. Chupakhin,
V. N. Charushin

Affiliations

A. V. Baklykov: I.Ya. Postovsky Institute of Organic Synthesis UB of RAS
A. A. Tumashov: I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
S. K. Kotovskaya: I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
E. N. Ulomskiy: I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
G. L. Rusinov: I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
V. L. Rusinov: I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
D. S. Kopchuk: I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
O. N. Chupakhin: I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin
V. N. Charushin: I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. Yeltsin

Journal volume & issue: Vol. 0, no. 4
pp. 98 – 102

Abstract

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A procedure for the simantenous determination of aminotriazole, triazolopyrimidinone and nirotriazolopyrimidinone was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted aminophase Zorbax NH2 (Agilent Technologies, USA). The possibility of applying the developed methodology for the technological control of the second stage of the drug «Triazid» preparation is established following the results of the validation.

Published in Разработка и регистрация лекарственных средств

ISSN: 2305-2066 (Print); 2658-5049 (Online)
Publisher: LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
Country of publisher: Russian Federation
LCC subjects: Social Sciences: Industries. Land use. Labor: Special industries and trades: Pharmaceutical industry
Website: https://www.pharmjournal.ru/

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