Medical Mycology Case Reports (Sep 2020)

Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response

  • Dunja Wilmes,
  • Daniela Schui,
  • Jürgen Held,
  • Sina Ackermann,
  • Udo Geipel,
  • Kai Emrich,
  • Ernst-Joachim Winkelmann,
  • Volker Rickerts

Journal volume & issue
Vol. 29
pp. 25 – 28

Abstract

Read online

We describe a patient with a disseminated coccidioidomycosis. Biomarkers in serum during itraconazole therapy showed a rapid clearing of Coccidioides DNA as detected by PCR. Coccidioides antibody detection by lateral flow assay became negative after one year and decreased from 1:64 to 1:8 in the complement fixation test after two years. The (1 → 3)-ß-D-glucan levels normalised after two years without increase after cessation of antifungal therapy. Biomarkers in serum may guide treatment decisions in disseminated coccidioidomycosis.

Keywords