Nature Communications (Jun 2022)
Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion
- Li-Qiang Wang,
- Yeyang Ma,
- Han-Ye Yuan,
- Kun Zhao,
- Mu-Ya Zhang,
- Qiang Wang,
- Xi Huang,
- Wen-Chang Xu,
- Bin Dai,
- Jie Chen,
- Dan Li,
- Delin Zhang,
- Zhengzhi Wang,
- Liangyu Zou,
- Ping Yin,
- Cong Liu,
- Yi Liang
Affiliations
- Li-Qiang Wang
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Yeyang Ma
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Han-Ye Yuan
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Kun Zhao
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Mu-Ya Zhang
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Qiang Wang
- National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research, Huazhong Agricultural University
- Xi Huang
- Department of Neurology, the Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital)
- Wen-Chang Xu
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Bin Dai
- Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University
- Jie Chen
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Dan Li
- Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University
- Delin Zhang
- National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research, Huazhong Agricultural University
- Zhengzhi Wang
- School of Civil Engineering, Wuhan University
- Liangyu Zou
- Department of Neurology, the Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital)
- Ping Yin
- National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research, Huazhong Agricultural University
- Cong Liu
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- Yi Liang
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- DOI
- https://doi.org/10.1038/s41467-022-31240-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Misfolded SOD1 has been linked to both familial and sporadic ALS. Here the authors have determined the cryo-EM structure of SOD1 fibrils, providing insights into the conversion of SOD1 from its immature form into an aggregated form during pathogenesis of ALS.
