Multistructured hydrogel promotes nerve regeneration

Ning Zhu; Yaping Zhuang; Wanju Sun; Juan Wang; Fan Wang; Xiaoyu Han; Zeyu Han; Ming Ni; Wenguo Cui; Yan Qiu

Materials Today Advances (Mar 2024)

Multistructured hydrogel promotes nerve regeneration

Ning Zhu,
Yaping Zhuang,
Wanju Sun,
Juan Wang,
Fan Wang,
Xiaoyu Han,
Zeyu Han,
Ming Ni,
Wenguo Cui,
Yan Qiu

Affiliations

Ning Zhu: Department of Pharmacy, Shanghai Pudong New Area People's Hospital, Shanghai, China; Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China
Yaping Zhuang: Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
Wanju Sun: Department of Orthopaedics, Shanghai Pudong New Area People's Hospital, Shanghai, China
Juan Wang: Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
Fan Wang: Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
Xiaoyu Han: Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
Zeyu Han: Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
Ming Ni: Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China; Corresponding author. Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wenguo Cui: Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Corresponding author.
Yan Qiu: Department of Pharmacy, Shanghai Pudong New Area People's Hospital, Shanghai, China; Corresponding author.

Journal volume & issue: Vol. 21
p. 100465

Abstract

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Hydrogels have emerged as promising biomaterials for nerve regeneration due to their adjustable properties, structural resemblance to the extracellular matrix, and ability to promote cell adhesion and proliferation. This comprehensive review discusses the advantages, challenges, and future directions of various functional hydrogels. Advanced technologies for fabricating Multistructured hydrogel, including injectable hydrogels, hydrogel microspheres, fibrous hydrogels, 3D printing hydrogels, nanogels, stem cell-loaded hydrogels, electrical hydrogels, ultrasound hydrogels, and magnetic hydrogels, have been developed and studied for nerve regeneration. These technologies demonstrate the versatility of hydrogels in neural tissue repair. However, challenges such as biocompatibility, degradation rates, and scaffold design need to be addressed. Interdisciplinary research is necessary to develop innovative hydrogel systems that overcome these challenges and realize the potential of hydrogels for nerve regeneration. This review provides valuable insights into advanced hydrogel technologies and highlights their potential in regenerative medicine, particularly in neural regeneration. Researchers can use this knowledge to refine therapeutic approaches involving hydrogels for enhancing nerve regeneration.

Published in Materials Today Advances

ISSN: 2590-0498 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-today-advances

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