PLoS ONE (Jan 2020)

Meconium microbiome and its relation to neonatal growth and head circumference catch-up in preterm infants.

  • Ana Carolina Terrazzan Nutricionist,
  • Renato S Procianoy,
  • Luiz Fernando Wurdig Roesch,
  • Andrea Lúcia Corso,
  • Andrea Lúcia Corso,
  • Priscila Thiago Dobbler,
  • Rita C Silveira

DOI
https://doi.org/10.1371/journal.pone.0238632
Journal volume & issue
Vol. 15, no. 9
p. e0238632

Abstract

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The purpose was identify an association between meconium microbiome, extra-uterine growth restriction, and head circumference catch-up.Materials and methodsProspective study with preterm infants born ResultsIncluded 63 newborns, GA 30±2.3 weeks, mean weight 1375.80±462.6 grams, 68.3% adequate weight for GA at birth. Polynucleobacter (p = 0.0163), Gp1 (p = 0.018), and Prevotella (p = 0.038) appeared in greater abundance in meconium of preterm infants with adequate birth weight for GA. Thirty (47.6%) children reached head circumference catch-up before 6 months CA and 33 (52.4%) after 6 months CA. Salmonella (pConclusionMeconium microbiome abundance was related to adequacy of weight for GA. Meconium microbiome differs between children who achieve head circumference catch-up by the 6th month of corrected age or after this period.