Multifunctional ultraflexible neural probe for wireless optogenetics and electrophysiology
Suhao Wang,
Lixuan Li,
Shun Zhang,
Qianqian Jiang,
Pengxian Li,
Chengjun Wang,
Rui Xiao,
Xiao-Ming Li,
Jizhou Song
Affiliations
Suhao Wang
Department of Engineering Mechanics, Soft Matter Research Center, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, and State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou 310027, China; Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China
Lixuan Li
Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Shun Zhang
Department of Engineering Mechanics, Soft Matter Research Center, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, and State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou 310027, China
Qianqian Jiang
Department of Engineering Mechanics, Soft Matter Research Center, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, and State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou 310027, China
Pengxian Li
Department of Engineering Mechanics, Soft Matter Research Center, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, and State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou 310027, China
Chengjun Wang
Huanjiang Lab, Zhuji 311800, China
Rui Xiao
Department of Engineering Mechanics, Soft Matter Research Center, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, and State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou 310027, China
Xiao-Ming Li
Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China; Department of Psychiatry and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Ministry of Education Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310030, China; Corresponding authors at: Zhejiang University, Hangzhou 310027, China.
Jizhou Song
Department of Engineering Mechanics, Soft Matter Research Center, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, and State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou 310027, China; Nanhu Brain-Computer Interface Institute, Hangzhou 311100, China; Huanjiang Lab, Zhuji 311800, China; Department of Rehabilitation Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Corresponding authors at: Zhejiang University, Hangzhou 310027, China.
Electrophysiology and optogenetics are pivotal in neuroscience for probing and modulating neural activities, playing a vital role in unraveling the complexities of brain functionality. Despite their importance, the efficacy of existing devices is hampered by insufficient functional integration, pronounced foreign body reactions, and physical constraints that impede natural animal behaviors. Here, we develop a multifunctional, ultraflexible neural probe designed for simultaneous electrophysiological monitoring and optical neural modulation, along with mechanical properties that are conducive to flexibility and compliance. By integrating a wireless neural signal acquisition and stimulation circuit, we achieved wireless recording of brain signals in mice and wireless optogenetic control over their locomotor behavior. The multifunctional ultraflexible probe presented in this study holds substantial promise for closed-loop brain-machine interfaces and deepening our understanding of neural circuit functions. This innovative approach addresses the aforementioned limitations by a comprehensive solution for in vivo neural interrogation and manipulation, marking a significant advancement in the tools available for neuroscience research.
