Nature Communications (Jul 2017)

Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival

  • Konrad Buscher,
  • Erik Ehinger,
  • Pritha Gupta,
  • Akula Bala Pramod,
  • Dennis Wolf,
  • George Tweet,
  • Calvin Pan,
  • Charles D. Mills,
  • Aldons J. Lusis,
  • Klaus Ley

DOI
https://doi.org/10.1038/ncomms16041
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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The inter-individual variation of the immune system broadly impacts pathophysiology. Here, the authors use the hybrid mouse diversity panel as a surrogate for human natural immune variation and derive a macrophages gene signature robustly correlating with susceptibility to macrophage-related disorders in humans.