Investigate the effect of metformin on some of the behavioral indicators in ovariectomized middle aged mice

Abstract

Introduction: Aging process is inevitable, which increases the risk of illness and death in people. Menopause occurs as a part of the aging process. The aim of this study was to evaluate the effect of metformin (Met) on muscle strength, anxiety and memory in ovariectomized mice Methods: Thiswas an experimental study. 96 female mice (Age 6 months) (20-25 g) were randomly divided into sex groups, including: (1) sham, (2) ovariectomized, (3 and 4) ovariectomized + Met (1 and 10 mg/kg) (5) Met 10 mg/kg, and (6) healthy. At first, the mice were ovariectomized and then received Met for six months. Muscle strength, memory, and anxiety in the exprimental groups was examined. Statistical analysis was performed via SPSS16 and the differences between groups were analyzed by one way ANOVA. Results: The results of the study showed Met with doses of 1 mg / kg and 10 mg significantly reduced the anxiety of mice (p = 0.0295 and p = 0.0024, respectively), increased memory (p = 0.0004 and p = 0.0044, respectively) and at dose of 10 mg / kg it improved muscle strength (p = 0.0148) compared to the ovariectomy group. Conclusion: Metformin has beneficial effects on behavioural manifestations of aging and ovarectomy

Keywords

• Aging
• Metformin
• Ovariectomy
• Muscle strength
• Memory
• Anxiety