CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn’s disease

L. Krabbendam; B. A. Heesters; C. M. A. Kradolfer; N. J. E. Haverkate; M. A. J. Becker; C. J. Buskens; W. A. Bemelman; J. H. Bernink; H. Spits

doi:10.1038/s41467-021-26187-x

Nature Communications (Oct 2021)

CD127+ CD94+ innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn’s disease

L. Krabbendam,
B. A. Heesters,
C. M. A. Kradolfer,
N. J. E. Haverkate,
M. A. J. Becker,
C. J. Buskens,
W. A. Bemelman,
J. H. Bernink,
H. Spits

Affiliations

L. Krabbendam: Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam
B. A. Heesters: Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam
C. M. A. Kradolfer: Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam
N. J. E. Haverkate: Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam
M. A. J. Becker: Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology & Hepatology, Amsterdam UMC, University of Amsterdam
C. J. Buskens: Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam
W. A. Bemelman: Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam
J. H. Bernink: Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam
H. Spits: Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam

DOI: https://doi.org/10.1038/s41467-021-26187-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Phenotypic markers that overlap between ILC1 and NK populations have impacted the robust and specific analysis of these immune cell populations. Employing scRNA sequencing here the authors identify CD127+ CD94+ innate lymphoid cells that express granulysin and perforin and are expanded in patients with Crohn’s disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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