Severe Aortic Valvular Incompetence From IgG4-Related Disease

Bing Wei Thaddeus Soh, MB; Sophie Catherine Prendergast, MB; Louise Burke, MD; Cormac T. O’Connor, MB; Ihsan Ullah, MBBS; Julie M. O’Brien, MB; John A. Hinchion, MB; Samer Arnous, MD; Thomas J. Kiernan, MD

JACC: Case Reports (Oct 2023)

Severe Aortic Valvular Incompetence From IgG4-Related Disease

Bing Wei Thaddeus Soh, MB,
Sophie Catherine Prendergast, MB,
Louise Burke, MD,
Cormac T. O’Connor, MB,
Ihsan Ullah, MBBS,
Julie M. O’Brien, MB,
John A. Hinchion, MB,
Samer Arnous, MD,
Thomas J. Kiernan, MD

Affiliations

Bing Wei Thaddeus Soh, MB: Department of Cardiology, University Hospital Limerick, Limerick, Ireland; Address for correspondence: Dr Bing Wei Thaddeus Soh, St Nessan’s Road, Dooradoyle, County Limerick V94 F858, Ireland.
Sophie Catherine Prendergast, MB: Department of Histopathology, Cork University Hospital, Cork, Ireland
Louise Burke, MD: Department of Histopathology, Cork University Hospital, Cork, Ireland
Cormac T. O’Connor, MB: Department of Cardiology, University Hospital Limerick, Limerick, Ireland
Ihsan Ullah, MBBS: Department of Cardiology, University Hospital Limerick, Limerick, Ireland
Julie M. O’Brien, MB: Department of Radiology, University Hospital Limerick, Limerick, Ireland
John A. Hinchion, MB: Department of Cardiothoracic Surgery, Cork University Hospital, Cork, Ireland
Samer Arnous, MD: Department of Cardiology, University Hospital Limerick, Limerick, Ireland
Thomas J. Kiernan, MD: Department of Cardiology, University Hospital Limerick, Limerick, Ireland; School of Medicine, University of Limerick, Limerick, Ireland

Journal volume & issue: Vol. 24
p. 102027

Abstract

Read online

IgG4-related disease (IgG4-RD) is a new clinical entity characterized by lymphoplasmacytic lesions rich in IgG4-positive plasma cells. Myocardial involvement is extremely rare and not a typical cardiovascular manifestation of IgG4-RD. We report a rare case of IgG4-RD–associated myocardial mass causing severe aortic incompetence, successfully treated with surgery and corticosteroids. (Level of Difficulty: Intermediate.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

About the journal

Abstract

Keywords