Nature Communications (Nov 2021)

The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes

  • Kay Oliver Schink,
  • Kia Wee Tan,
  • Hélène Spangenberg,
  • Domenica Martorana,
  • Marte Sneeggen,
  • Virginie Stévenin,
  • Jost Enninga,
  • Coen Campsteijn,
  • Camilla Raiborg,
  • Harald Stenmark

DOI
https://doi.org/10.1038/s41467-021-26775-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.