Nature Communications (May 2021)

Total genetic contribution assessment across the human genome

  • Ting Li,
  • Zheng Ning,
  • Zhijian Yang,
  • Ranran Zhai,
  • Chenqing Zheng,
  • Wenzheng Xu,
  • Yipeng Wang,
  • Kejun Ying,
  • Yiwen Chen,
  • Xia Shen

DOI
https://doi.org/10.1038/s41467-021-23124-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

Read online

Quantifying the effects of individual loci on the human phenome is a challenging task. Here, the authors introduce a modelling technique, TGCA, that assesses total genetic contribution per locus and apply this to UK Biobank phenotype domains, revealing top loci and links to tissue-specific gene expression.