Nature Communications (Sep 2018)

Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway

  • Jingbo Dai,
  • Qiyuan Zhou,
  • Jiwang Chen,
  • Megan L. Rexius-Hall,
  • Jalees Rehman,
  • Guofei Zhou

DOI
https://doi.org/10.1038/s41467-018-06376-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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Metabolic reprogramming of smooth muscle cells (SMCs) plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH). Here, Dai et al. show that the glycolytic enzyme alpha-enolase contributes to this reprogramming, and that its inhibition limits SMC proliferation and disease progression in animal models of PAH.